아달리무맙 문서 원본 보기

'''아달리무맙 (adalimumab)'''{{망막}} (Humira® (휴미라), AbbVie, Chicago, IL, USA) 은 완전 인간 단일 클론 론 IgG1 TNF-α 항체이다.
== 효과 ==
비감염성 포도막염의 치료에 효과가 있는 것으로 입증된 생물학적 제제로<ref>Jaffe GJ et al. Adalimumab in Patients w Active Noninfectious Uveitis. ''NEJM''. 2016 Sep 8;375(10):932-43. [https://pubmed.ncbi.nlm.nih.gov/27602665/ 연결]</ref><ref>Nguyen QD et al. Adalimumab for prevention of uveitic flare in patients w inactive non-infectious uveitis controlled by corticosteroids (VISUAL II) : a multicentre, double-masked, randomised, placebo-controlled P3 trial. ''Lancet''. 2016 Sep 17;388(10050):1183-92. [https://pubmed.ncbi.nlm.nih.gov/27542302/ 연결]</ref><ref>Neri P et al. Adalimumab (Humira™): a promising monoclonal anti-TNFα in ophthalmology. ''Int Ophthalmol''. 2011 Apr;31(2):165-73. [https://pubmed.ncbi.nlm.nih.gov/21287227/ 연결]</ref>, 강직성 척추염<ref>Rudwaleit M et al. Adalimumab effectively reduces the rate of anterior uveitis flares in patients w active AS : results of a prospective open-label study. ''Ann Rheum Dis''. 2009 May;68(5):696-701. [https://pubmed.ncbi.nlm.nih.gov/18662932/ 연결]</ref>과 소아 포도막염<ref>Mansour AM. Adalimumab in the therapy of uveitis in childhood. ''BJO''. 2007 Mar;91(3):274-6. [https://pubmed.ncbi.nlm.nih.gov/17322463/ 연결]</ref>, 그리고 난치성 포도막염<ref>Lee JT et al. Adalimumab for the treatment of refractory active and inactive non-infectious uveitis. ''BJO''. 2018 Dec;102(12):1672-1678. [https://pubmed.ncbi.nlm.nih.gov/29459430/ 연결]</ref><ref>Díaz-Llopis M et al. Treatment of refractory uveitis w adalimumab : a prospective multicenter study of 131 patients. ''Ophthalmology''. 2012 Aug;119(8):1575-81. [https://pubmed.ncbi.nlm.nih.gov/22525047/ 연결]</ref>에서도 효과가 있음이 보고된 바 있다.
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